The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the nih on the principles and practice of clinical research molecular medicine genomics and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research as an introductory . The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the nih on the principles and practice of clinical research molecular medicine genomics and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research as an introductory . Principles and practice of clinical research second edition barker ruth rrt nps critical care medicine july 2008 volume 36 issue 7 p 2223. This is a comprehensive major reference work for our springerreference program covering clinical trials although the core of the work will focus on the analysis and interpretation of scientific data gleaned from the trial process a broad spectrum of clinical trial principles and practice areas will be covered in detail. The introduction to the principles and practice of clinical research ippcr course trains registrants on how to effectively and safely conduct clinical research